Primordial Germ Cell (PGC)

Primordial Germ Cell (PGC)

  • It is pluripotent
  • Synthesized by epiblast in 2nd week → Migrate to endodermal wall yolk sac in 4th week → Reach the gonads by 5th week
  • Sometimes the PGC reach the neck region (craniopharyngeal teratoma) and sometimes they migrate to the region between sacrum and coccyx (sacrococcygeal teratoma). The term “Teratoma” is used because of the plueripotency of the PGC.


Terms :

Totipotency :

  • Ability to form entire embryo and extra embryonic tissue
  • Upto 8 cell stage every cell is totipotent

Plueripotency :

  • Ability to form all germ layers

Multipotency :

  • Form more than one category of cells
  • Hematopoietic stem cells

Oligopotency :

  • Form one category of cell
  • Vascular stem cells

Unipotent cells :

  • Form only one type of cell
  • Liver cell

Meiosis takes place two times – meiosis 1 and meiosis 2.

Prophase → Metaphase → Anaphase → Telophase.



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